Brain of Mensis

Enemy Type Not Beast nor Kin
Health 9837
Drops Living String,  2181 Blood Echoes
Weak ??
Strong ??
Location Nightmare of Mensis

Brain of Mensis is an enemy in Bloodborne.

The Brain of Mensis , also known as "Mother Brain", is an enemy resembling a giant brain with various eyes and some beastly limbs. It is essentially a large version of Winter Lanterns, though without a body.

It is first encountered from a distant tower at the beginning of Nightmare of Mensis,  and will glow orange when the player is in line of sight, causing massive frenzy damage. This attack can hurt the player even from a very long distance, unless the environment is used to avoid its malignant gaze.

The Brain of Mensis  can be slain after defeating Micolash, Host of the Nightmare. The player can defeat it by using a lever in a side area, dropping the brain into a pit where it will be unable to attack the player further.



  • Have 10 Sedatives equipped. Awaken at the Mergo's Loft: Middle lantern, and get into the bird cage elevator. During descent, there is a window you can jump into from the elevator.
  • Run across the bridge with the 3 Winter Lanterns, using the terrain and Sedatives to avoid Frenzy.
  • In the building, run past the Nightmare Apostles, descend the stairs, and pull the lever on the balcony, triggering a cut-scene that drops the Brain of Mensis  into a pit.
  • After the cut-scene, turn around and drop down into a hole on your right.
  • In the room, there are two spiders and a chest holding the Choir Bell item which is guarded by a Winter Lantern.
  • Run outside, jump down into the collapsed tower (avoiding the bottomless pit) and there is a body holding the Blood Rock.
  • Follow the path out onto the bridge and enter the building with Mergo's Attendants.
  • Go to the bottom floor with the holes in the ground, and ride the bird cage elevator located on the right side.
  • You will enter a pitch-black room where the Brain of Mensis  is now helpless and easy to kill.
  • IMPORTANT NOTE: Before attacking the brain, use the "Make Contact" gesture in front of it until your character's arms rotate, and you will receive the Tier 3 Moon Caryll Rune (Great One's Wisdom in NG+ if you already have it).



Attack Name Attack Description
Gaze If the player is within its line of sight, he/she will take continuous damage from this far-reaching attack.

NeoMerdien - video guide:

  • how to
  • how to


The Brain of Mensis Information

This enemy is unique as an important part of the story, and it is only found in one area in the game. There are no variants nor is it encountered in Chalice Dungeons.

living_string.png moon.jpg
Nightmare of Mensis 9387 2181 (1x) 100% (1x) 100%


Notes & Trivia

  • The Living String description states the Brain of Mensis is a Great One and was found in the Nightmare by Mensis.
  • The Brain of Mensis is the one attacking you with Frenzy as you try to make your way to the building and Mergo's Loft.
  • The location where the Brain of Mensis is dropped after you pull a lever in Nightmare of Mensis is completely pitch black on all of its surfaces, resembling the Abyss of Dark Souls.
  • It will not disappear from the game after you kill it, it will still drop blood echoes but no Living Strings (hence why the Nightmare of Mensis still remains).
  • You must use the "Make Contact" gesture in a very specific location, infront of the hand, in order to obtain the rune.
  • You can also do the "Make Contact" gesture after killing it (it doesn't have to be physically present) and still get the full Moon Caryll Rune.
  • There seems to be a bug where killing it with a cooperator can cause you to not receive the Living String.
  • The brain is often referred as "rotten" leaving us to believe that it may have corrupted the Dream of Mensis and made it the Nightmare of Mensis, as well as Micolash, who was the leader of the School of Mensis.



Amygdala  ♦  Beast Claw Hunter  ♦  Beast Cutter Hunter  ♦  Beast-possessed Soul  ♦  Beast-possessed Soul (Mob)  ♦  Black Widow  ♦  Blood Dobermann  ♦  Blood Gel  ♦  Blood-Starved Beast  ♦  Bloodletting Beast  ♦  Bloodsucking Beast  ♦  Bloody Crow of Cainhurst  ♦  Bone Ash Hunter  ♦  Boom Hammer Hunter  ♦  Bosses  ♦  Brador  ♦  Brain Trust  ♦  Brainsucker  ♦  Brick Troll  ♦  Byrgenwerth Spider  ♦  Cainhurst Hunter  ♦  Carrion Crow  ♦  Celestial Centipede  ♦  Celestial Emissary  ♦  Celestial Larvae  ♦  Celestial Mob  ♦  Chapel Giant  ♦  Chime Maiden  ♦  Church Doctor  ♦  Cleric Beast  ♦  Crawler  ♦  Darkbeast Paarl  ♦  Deep Sea Hound  ♦  Djura  ♦  Ebrietas, Daughter of the Cosmos  ♦  Enlarged Head Giant  ♦  Enlarged Head Patients  ♦  Ethereal Walker  ♦  Executioner  ♦  Eye Collector  ♦  Father Gascoigne  ♦  Fishwitch  ♦  Gel  ♦  Gravekeeper Scorpion  ♦  Graveyard Hags  ♦  Greater Viper Pit  ♦  Hamlet Fishmen  ♦  Henryk  ♦  Hostile Choir Hunter  ♦  Hostile Hunters  ♦  Hunter Mob  ♦  Hunting Dog  ♦  Keeper's Hunting Dog  ♦  Keeper of the Old Lords  ♦  Labyrinth Mole  ♦  Labyrinth Rat  ♦  Large Huntsman  ♦  Lightning Summoner  ♦  Loran Cleric  ♦  Mad One  ♦  Madman  ♦  Maneater Boar (Mob)  ♦  Mannequin  ♦  Martyr Logarius  ♦  Merciless Watcher  ♦  Merciless Watcher (Mob)  ♦  Mergo's Attendant  ♦  Mergo's Wet Nurse  ♦  Mi-Go Zombie  ♦  Micolash, Host of the Nightmare  ♦  Moon Presence  ♦  Nightmare Huntsman  ♦  Old Yharnam Beast  ♦  Old Yharnam Hunter (Mob)  ♦  One Reborn  ♦  Piercing Rifle Hunter  ♦  Protector  ♦  Pthumerian Descendant  ♦  Pthumerian Undead  ♦  Rabid Dog  ♦  Rat  ♦  Reaper  ♦  Ritual Master  ♦  Rom, the Vacuous Spider  ♦  Saif Hunter  ♦  Shadow of Yharnam  ♦  Shadow of Yharnam (Mob)  ♦  Shark-Giant  ♦  Silver Lady  ♦  Silverbeast  ♦  Slime Scholar  ♦  Slug  ♦  Snail Woman  ♦  Snake Ball  ♦  Snatcher  ♦  Sorrowful Emissary  ♦  Tomb Guardian  ♦  Tomb Inspector Hunter  ♦  Tormented Nanny  ♦  Undead Amalgam  ♦  Undead Giant  ♦  Undead Giant (Mob)  ♦  Vengeful Specter  ♦  Vermin Host  ♦  Vicar Amelia  ♦  Viper Pit  ♦  Watchdog of the Old Lords  ♦  Watcher's Gravedigger  ♦  Wheel Hunter  ♦  Wheelchair Mob  ♦  Witch of Hemwick  ♦  Witch of Hemwick (Mob)  ♦  Wolf Beast  ♦  Wrathful Stinger  ♦  Wretched Undead  ♦  Yahar'gul Hunter  ♦  Yeti  ♦  Yharnam, Pthumerian Queen


Join the page discussion Tired of anon posting? Register!

    • Anonymous

      28 Jun 2020 17:56  

      if you kill it without getting the rune you can come back later and it will respawn so you can still get the rune

      • 18 Apr 2020 17:10  

        Has anyone else encountered the brain AFTER killing it? I had forgotten to get the Moon rune before killing the brain. I went back to use the "make contact" gesture, since I found a comment stating that you can get the rune anyway. When I got out of the elevator I ran straight, the brain was not there as expected. Then I realized that the heartbeat sound was present. I went back to the elevator and then noticed a faint silhouette to the right, approached it and discovered the brain! Has this happened to anyone else? By the way, I used the gesture in front of the second brain and it gave me the rune. I did not killed it this time.

        • Anonymous

          06 Jan 2020 18:39  

          Think what you will of me, but the make contact gesture when I do it in front of this being is like justifying its godly self with its other great one brethens, even if it can do nothing but frenzy you until its near end. Maybe thats why it gives you a rune and/or a great one's wisdom in appreciation to you still accepting it among its peers as it lies before you with nothing noteworthy to spare in comparison to its other great ones, as the 'make contact' gesture is to accept and recognize the gods of the dream before yourself as a human, virtually 'worshipping' them. Either that or its frenzy was a cry for help for you to release it from its shackles among the tower it was forced to commence to keep the nightmare of mensis alive, and then you kill it to pull it out of its forceful misery. Whatever the case, I feel bad for this parasite looking creature.

          • Anonymous

            18 Jun 2019 02:42  

            It's so ugly that it's kind of adorable and I always feel like I'm murdering a puppy when I kill it. Why can't we keep it, mom?! I swear I'll walk it...and use it to destroy my enemies

            • Anonymous

              11 Dec 2018 02:32  

              :< Sorry for smashing ya, eyeball. Don't look at me like that... die already..please die.. where is my satisfaction .. goddamit miyazaki !

              • Anonymous

                20 Sep 2018 16:00  

                Visually it reminds me of a teratoma, a type of tumor that is comprised of various types of tissue, capable of forming hair, teeth, eyes, and even brain tissue. Some even grow limbs or develop into what look like malformed fetuses. Perhaps the Brain of Mensis really does represent the “stillbirth” of the scholars’ brains.

                • Anonymous

                  19 Aug 2018 18:39  

                  Does anybody know what this is whispering, whilst in the pit? All I'v been able to understand is "Please save me from..."

                  • Anonymous

                    17 Feb 2018 06:08  

                    Caryll Runes are are visual translations of langue of the great ones and I have to ask, why is this great one telling you about the moon?

                    Description of the moon Rune - “A secret symbol left by Caryll, runesmith of Byrgenwerth.
                    A transcription of "moon", as spoken by the Great Ones inhabiting the nightmare.

                    Gain more Blood Echoes.
                    The Great Ones that inhabit the nightmare are sympathetic in spirit, and often answer when called upon.“

                    Indeed, this great one made contact upon being interact on and said “Moon.” Why?

                    I hypothesis this great one is asking you to find and kill the Moon Presence. Just a theory, I mean there has to be a reason it said Moon.

                    • Anonymous

                      16 Aug 2017 00:45  

                      If anyone is wondering why you get frenzy, I assumed this game had heavy Lovecraftian influences. In the stories humans often went insane trying to comprehend otherworldly beings. I'm assuming Frenzy state and Madman knowledge is connected. Since the more Madman Knowledge you have in you inventory the more fatal frenzy will be to your health. As the more knowledge of the cosmic horror the more insane your mind is. It also explains why you start to see the old ones hanging in spots early on in the game the more knowledge you have.

                      • Anonymous

                        07 Jun 2017 10:10  

                        I wonder if this thing is really TRYING to kill you with Frenzy, or if it's just calling out to you for some reason, maybe even for help. I get the feeling it doesn't really want to be strung up in that tower, plus it seems pretty chill when you make contact. Maybe... it's even trying to get you to kill it? It's also incredibly okay with you bashing its brains out (no pun intended).

                        Also, those "beastly limbs" look a lot like withered versions of Amygdala's arms. The hands have six fingers, and there's a strange hole in the center of each palm. Though this detail is also seen in the scurrying creatures that carry the blood shards, which is kinda weird, so I'm not sure if this is directly relates the Brain to Amygdala or those hands are just a recurring detail.

                        • Anonymous

                          16 Apr 2017 19:33  

                          Anyone looked real closely at the "body" of the brain. The parts which arent eyes/tentacles/hands appear to be made up of messengers.. Think on that

                        Load more
                        ⇈ ⇈