- Harrowed Hunter at the elevator leading to the Research Hall
- Saint Adeline in the room at the first floor of the Research Hall. Needs to be accessed from the back and the higher floors.
- Enlarged Head Patient NPCs
- Antidote x2
- Beast Blood Pellet x6
- Blood Stone Chunk x?
- Blue Elixir x10
- Brain Fluid (Quest Item, x3)
- Dirty Damp Blood Gem (5)
- Finestrike Damp Blood Gem (5)
- Frenzied Coldblood (9)
- Great One's Wisdom
- Kin Coldblood (10) x2
- Lethal Damp Blood Gem
- Madman's Knowledge x?
- Milkweed Carryl Rune
- Pulsing Damp Blood Gem
- Sedative x8
- Loch Shield
- Church Cannon
- Carrion Crow
- Church Servant
- Enlarged Head Patients
- Enlarged Head Giant
- Wheelchair Mob
- Giant Rat
- Scurrying Beast x3
- Presumably where the Healing Church conducted experiments on humans in an attempt to create beings capable of communication with the great ones. Many of the enemies in the area are the failed results of these early experiments, although the Healing Church would eventually find success in this endeavour, creating the Celestial Emissary.
- The presence of a Lumenflower garden direcltly above to that found in the Upper Cathedral Ward (location of Celestial Emissary boss fight) suggests that this secret research facility was at one time a part of the same complex.
Upon finishing the cutscene where you are shown riding up the elevator from the Surgery Altar, you will find yourself in a darker area, with a lamp just ahead to your left. Go ahead and light it. You'll want to stop by here every now and then to spend your blood echoes. Before you actually head into the Research Hall proper, take the elevator back down. Step back on as if to ride back up and then quickly step off again to make the elevator ascend. A second elevator floor will rise up from the floor below. Step onto it and it will go down. On the alter of the second elevator is Laurence's Skull. Once the elevator reaches the bottom, step off into a small room and open a chest to obtain the church cannon, then ride the elevator back up, pull the leaver to the right to bring down the second elevator, and continue back up to the Research Hall.
In front is a staircase leading up to the Research Hall, a vertically designed level full of convoluting staircases and insane patients with enlarged heads. Head up the stairs and to your left you will see a Scurrying Beast. Dispatch it quickly, and you will be rewarded with x2 Blood Stone Chunk. Next, take a look at the pool in the center of the large chamber. On the edge is a non-hostile version of the majority of the enemies that you'll be facing in this area, an insane patient with a huge head. Approach him, and he will begin to ask if anyone has seen his eyes. This is about as useful as he gets, so instead, turn your attention to the pool again. Next to the large central column is a corpse containing x2 Blue Elixir. You'll want to move quickly, as the water will build up your slow poison meter.
At the back of the chamber, on the edge of the pool, is another Wandering Madness. Kill it to earn yourself another x2 Blood Stone Chunk. There is also a door marked “1st Floor Balcony”, but it's locked right now, so head back to the entrance.
From here, head toward the large staircase. Be careful as you ascend, because you'll likely draw the attention of a patient or two. Like most enemies, these can be stunlocked into a kill relatively easily, but you'll want to be on your guard, as they can attack suddenly and pack a punch, especially with their flailing attack, which can stunlock you into a quick death. Be mindful of when they run at you, as the attack that follows is usually a headbutt. With their heads being distended and filled with fluid you may think you're just out of reach but their heads, disgustingly enough, will stretch during this attack and it does a lot of damage if you're caught by it.
It's also worth bearing in mind that the patients are blind, they become aggressive and chase you based on the sounds they can hear. Bottles, vials and jars all litter the ground meaning when you step on them they can hear you. If you stand perfectly still, or walk very slowly, they won't be able to hear your movements if they're not patrolling.
Once they are defeated, head up to the small landing, where you will encounter more patients. Dispose of them, then head up the staircase on the right-hand side. At the top, turn left, and head down this way. At the end is an enemy, but there is also another enemy hiding behind the shelves. After you kill them, watch your back, because more patients will be approaching. After taking them out, head over to the nearby corpse to pick up the x2 Blood Vial. To your right is a doorway hidden by medical equipment. Inside are non-hostile patients. Talk to them if you'd like, then head back outside, and back down the balcony. There will be a doorway on the left marked “Patient Room 2”. Head inside, but be careful, as there are a ton of patients in this area, including one that will ambush you immediately from the left side. Be wary of your above left, as there are a couple patients on the balcony that will throw acid jars at you. Deal with the creatures on the ground floor, then dispatch the wave of enemies that come down the stairs. After they are dead, head up the stairs and clear the balcony with the acid throwing patients on it.
Now that the area is clear, head back down the stairs and pick up the x3 Sedative from the corpse in the back left corner. Next, head back up the stairs and proceed through the doorway, then climb up the ladder. At the top, you will encounter a new enemy. He is similar to the other patients, but is taller, and wields a medical drip. He attacks both quickly and slowly, and chains together some pretty unpredictable combos, as well as being difficult to stagger, so your best bet is to just visceral attack him until he lies dead.
Now that it's safe, head to the far left corner to pick up the x5 Blood Vial, and head out the left exit of the room, up the stairs. At the top, head out the door onto the balcony. Far off to your right, you'll notice some more patients, but don't be too quick to engage, as there are quite a few of them that will walk out from the nearby room, and running into the bottles on the ground will alert them to your presence. As they walk up the stairs, they will quickly be killed by the gatling gun of a Wheelchair Mob. After they have all been killed, make your way along the balcony, picking up the x2 Antidote on the left outcropping.
Head into the room on the right at the end of the balcony, and deal with any remaining enemies, but be careful, as the room is dark and you'll likely be ambushed by a patient with a deformed arm. If he grabs you, you will take continuous damage, as well as being poisoned. Once the room is clear, head to the far end to pick up the x3 Quicksilver Bullets, then ascend the steps to your right. Turn right at the top to find a corpse with x1 Dirty Damp Blood Gem (5).
Head back down the stairs and out the door. Begin climbing the staircase in front of you, and immediately launch into a sprint, running all the way up onto the next landing to avoid the hail of fire from the gatling gun. At the top, head down the staircase on the right, and turn right. At the end of this balcony is the enemy that attacked you with the gatling gun. Don't take your revenge too quickly, though, as there is a trap on the way there. Make note of the shelves lined with jars on the left hand side. Down the balcony a ways, there will be a pressure pad with bottles on it. Stepping on this will cause the nearby shelves to send deadly acid flying outward. After avoiding the trap, deal with the enemy in the wheelchair, being careful not to get caught in the stream of bullets.
Head back down the balcony and through the door on the right marked “Laboratory Floor 5”. Head up the steps and into the elevator, which will take you downward. Be careful exiting the elevator, as there is a wheelchair enemy on the right that will spew acid at you. Deal with him quickly, then take care of the two wheelchair enemies on the other side of the room, both wielding pistols. After dealing with them, head over to the nearby corpse to pick up x6 Beast Blood Pellet.
Head back to the other side of the room and pull the lever on the left side to call up the elevator. Once it arrives, head inside and ride it down. At the bottom, you'll find yourself in a room with an npc, Saint Adeline, in the far left corner. Don't mistake her as an enemy, because she provides important items! Approach her and she will begin speaking. Talk to her again and she will ask you to find her some Brain Fluid. We don't have any yet, but we'll find some soon. Head to the door on the right, and open it. You'll find yourself back in the starting area, with the lamp just a short jog away. Visit the Hunter's Dream if you need to, then head back up the elevator into the room with the wheelchair enemies. Take a left out the door, and deal with the Church Servant, being careful not to roll off of the edge.
Take a left, but be careful, as there is another pressure pad trap here. Avoid it, and approach the naked patient at the top of the stairs on the right. These enemies are faster and attack more erratically, so be careful. They tend to leap straight at you with a flailing melee attack. Your best bet is to bait the leap out and dodge round them. When they land they're still for a second or so leaving you ample opportunity to get in with a combo and kill them. Bear in mind that they have ~ 2x the HP of the normal patients. Once he has been dealt with, turn your attention to the item on the far wall. Avoid the final pressure pad trap on the way, and pick up the x1 Madman's Knowledge.
Head back to the elevator room and enter the elevator on the left. As it starts to move, press against the left-hand wall, and start walking forward. As the elevator rises, you will jump out into a secret hallway. Head forward and turn left when you're out on the balcony. Continue forward to the end of the balcony and descend the steps to your right, but be careful, as there is a hunter here. An easy way to deal with him is to quickly run past him to the left, and around the middle of the platform, staying on the other side of the brain creature. This is because he will try to run after you, and will get stuck between the brain and the pillar. Once he's stuck, just hit him with long range weapons, such as the transformed Saw Cleaver or the transformed Threaded Cane.
Once the hunter has been dealt with, pick up the x5 Sedative he drops and head over to the now most likely dead brain creature. Pick up the Brain Fluid and about face. On the side of the platform opposite the staircase, you can drop down onto another staircase. Once you do, be prepared for two rats to fall from above. Deal with them, and head down the stairs to the landing, then head down the next flight of stairs. At the bottom, turn left and head out the door to end up outside. To your left is a patient tending to a sunflower. You can talk to him, but he won't make much sense, so head back inside.
Once inside again, move forward along the balcony. There is a patient ahead. These variants crawl, and try to leap on you constantly. Once it is dealt with, grab the x1 Frenzied Coldblood (9) in the corner, and turn around. Head back down the balcony, and stop when you reach a door on your right, marked “Laboratory Floor 2”. Inside, there are two more crawling patients that will attempt to ambush you. Kill them off, and head over to the nearby corpse to obtain the Decorative Old Hunter Set chest piece and trousers. Once you're done, head up the stairs on your right and ascend the ladder. You'll find yourself back in the elevator room.
Now that we have the brain fluid, we can go ahead and give it to Adeline. Take the left elevator down to her room, and offer it to her. She will then offer her blood. Accept it, and head back up in the elevator. Head into the lift opposite to emerge onto the highest balcony. Take the stairs directly in front of you, then head up the next staircase on the right. At the top, you will encounter another tall, drip-wielding patient. Kill him, and head up the ladder.
You will find yourself in the tower's belfry. There a couple of rats walking around here, so be mindful of them, and be careful not to fall. Head over to the item on the far beam, but be careful, because as you approach it, a crow will fall from above. Deal with the crow, then pick up the x1 Great One's Wisdom. Next, head over to the window on the far side of the belfry. Speak with the patient bashing his head against the wall to get some more dialogue, then head right. There are a couple of crows guarding an item. Defeat them, and pick up the x1 Blood Stone Chunk. Turn around, and head over to the beam closest to you. Follow it halfway, and descend the steps on the right to the middle platform. Interact with the lever here to raise middle pillar and its staircases, altering the entire level.
The way to the boss is now open, but there are a few more items to pick up in this area before we challenge it. Once the platform stops moving, head onto the beam opposite the window and turn left at the end of it. You'll find another brain creature. Attack it to get the second helping of Brain Fluid.
Head back in the opposite direction along the beam and you'll find a ladder. Descend it and then head down the steps. Take the left staircase down to a chest guarded by a few crows. Open the chest to find x1 Finestrike Damp Blood Gem (5). Turn around and head back up the stairs, and this time, take the other staircase downward, but be careful, as there some naked patients at the bottom, and the staircase has no railing. After these enemies have been dispatched, head down the the balcony, where you'll come across the headless variant of the patients. These are blind, and will not see you if you walk by them, but they have increased poise, and don't flinch away from your attacks. Dispose of them and turn right, heading to the end of the balcony, minding the trap on the floor as you go by. At the end, pick up the x4 Blue Elixir, and head back along the balcony, stopping as you reach a door on your right, marked “Patient Room Floor 5”. Head inside, and go to the far side of the room to find x4 Blue Elixir. The item next to this is the Enlarged Head, but be careful, because the brain creatures in the room will begin to attack when you pick it up. These enemies build up frenzy with their tentacle attacks, so be extra careful. There is another brain creature on the ceiling at the room exit, and it will try to fall on your head as you leave.
When it's safe, head back outside and turn right. Follow the balcony all the way around the room, eliminating any patients along the way (be careful of that trap on the floor from earlier!). Head into the room on the right at the end, and take the elevator down, heading out into the secret hallway again as you descend. Take a left on the balcony, and follow it until you arrive at a staircase on your right. Head on down, and take out any patients you encounter. If it's safe, head up the left staircase. At the top, there will be more patients, coming from both sides. Deal with them, and head left along the balcony until you see a corpse on the left with an item. Walk over to it and pick up the x4 Quicksilver Bullets.
Head over to the room on the right marked “Patient Room Floor 3”. As soon as you enter, you will be ambushed from the right by a patient with a deformed arm. Make sure he doesn't grab you, then dispose of him. Inspect the body to find the Underground Cell Key. This key will unlock all of the cells in the previous area.
Travel back out to the balcony and move along it, heading back down the staircase when you arrive at it. When you arrive back at the central platform, head down the stairs to the left. Here you will encounter a worm-like variant of the patient. Don't be fooled by its size, this thing can pack a punch with its attack that involves shooting tendrils out of its face in your direction. After it's dead, head over to the corpse to find the Loch Shield.
From this platform, you can drop back down onto the ground floor below. This area is different from before, as it is covered with the worm patients, and there are some new items in the pool. The one by the pillar is a x1 Lethal Damp Blood Gem (5), and the one in the corner is a x1 Kin Coldblood (10).
After collecting the items, head back into Adeline's room, where she will seem to be in distress. Talk to her and she will ask for more brain fluid. Make sure you have used her blood before this. If the dialogue does not trigger, try running to the lamp and resetting the area until she finally accepts the second dose of brain fluid from you. After she takes it, she will provide you with the Balcony Key. This is the key we need for that door that was locked at the start.
Key in hand, head out of Adeline's room, and make your way to the far side of the chamber to the door marked “1st Floor Balcony”. Unlock the door, and head on through. Outside is an area that looks a lot like the Lumenflower Gardens in the Upper Cathedral Ward. There are a lot of patients here, and they attack differently from the other ones, using magic attacks.
Drop down onto the roof, then onto the little outcropping, before finally landing on the balcony overlooking the garden. Head left and around the top of the garden to the corpse on the far side, and pick up the x1 Kin Coldblood (10). When you're ready, head down into the garden below. You can either fight the enemies here, or make a bee-line for the Blacksky Eye at the end. After picking it up, turn around, and head for the large window. Break it, and jump down to the cathedral balcony. Take a left and defeat the Scurrying Beast to obtain x2 Blood Stone Chunk. Head back around the balcony towards the chest. Jump over the gap, and open the chest to receive x1 Pulsing Damp Blood Gem (5).
Head back to the hole in the floor, and drop down onto the ledge. From here, drop down on top of the bed, and then drop to the floor. You'll find yourself back at the Surgery Altar. From here, you can go unlock the cells, or you can take the elevator back up to the Research Hall.
Once you're back at the research area lamp, you'll see the Harrowed Hunter again. He will tell you that you should climb the Astral Clocktower and kill Maria. Head back into the Hunter's Dream to spend your hard earned blood echoes. Once you're back, head back to Adeline's room. Provided you've reloaded the area, you can now complete her questline by attacking her to release the final Brain Fluid, and then giving it to her to receive the Milkweed rune. After that, head into the elevator, and when you get to the top, walk out the door to your left.
Out on the balcony, deal with the enemy once again and take a right. Take the staircase up to the platform, and then from there, take the next staircase on the right up to the boss door, where you will hear a patient lamenting to Lady Maria. Beyond this door lie the Living Failures. If you have the Impurity rune equipped, you can summon the Old Hunter Yamamura, provided you killed him in his cell earlier. If not, you can always go back and do so. Whatever you do, be prepared for an interesting boss fight ahead.
(Work in progress!)