Brain Fluid is a Key Item in Bloodborne.
brain_fluid.jpg "Greyish amoeba-shaped brain fluid. Wobbles and bounces.

Extracted from a patient whose head expanded until that was all that they were.

In the early days of the Healing Church, the Great Ones were linked to the ocean, and so the cerebral patients would imbibe water, and listen for the howl of the sea. Brain fluid writhed inside the head, the initial makings of internal eyes.

Once, a young girl had an older brother who was determined to become a doctor, and so she wilfully became his patient. In the end, this led to their encounter with the Eldritch Truth, for which they considered themselves blessed.

We fail to realize our own latent potential, until the moment it is lost, and we sense its absence. Ironically, this is the very nature of insight, like the moment one licks one's own blood, only to be startled by its sweetness."

Brain Fluid Usage

  • Brain Fluid is given to Saint Adeline to progress an in-game quest to receive the Milkweed Caryll Rune. There are 3 places to find it.


  • Drops off the enlarged head at the highest point of the research hall on the uppermost catwalk in the corner across a crow. This is accessed after turning the main tower in the Research Hall. (Can be reached early by dropping to another platform close to where you reached the top level and climbing up another ladder)
  • Drops off the enlarged head on the middle platform that is guarded by a hunter and minigun user in a wheelchair.
  • Drops off of Saint Adeline after she has turned into an enlarged head without a body. She comes back to life after killing her for the fluid.
  • This item can only be gotten once per enlarged head (including Adeline).
  • Hostile enlarged heads do not drop this.


  • Player note 1


Trivia goes here

*Note* Saint Adeline must be given the first 2 Brain Fluids before she will turn into a enlarged head herself. Returning to the Hunters Dream multiple times seems adequate to move her in between in between states which will cause her to ask for more Brain Fluid.

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    • Anonymous

      21 Jul 2021 12:36  

      I like the comment on insight. Something that you don't realize is there, but recognize it's absence. The phrasing there means something different. It's not that you notice that you've lost it, but that losing it changes your perception. You know something is different, but not why it's different. I think that's the what the " the moment one licks one's own blood, only to be startled by its sweetness." means. You're closer to beasthood, and now blood is addicting to you, but you don't know why. It just is. But it's because you lost something you didn't know you had.

      However, I think it also comments on the desire for insight. Several characters were seeking what we could call insight in the game. Micolash, seeking to be "granted eyes" from Kos, or Master Willem and the students of Byrgenwerth. I believe they thought this insight would elevate them to the "higher plane", like what Kos did to Rom. But insight is only known via it's absence, right? So they went further and further. Thinking they didn't have it yet, because if they did, they would transcended. But they did have it. They just didn't realize they had it. They searched endlessly for something they already had, and the more they got, the madder they went.

      It's just an idea. But I really like how this one piece of lore about insight opens the door to some cool theories.

      • 10 Aug 2020 09:58  

        you'll know when it's time to kill Adeline because she'll have escaped the chair and she'll be in the corner of the room next to the door. her death is awful :(

        • Anonymous

          10 May 2020 03:44  

          Whoever made this page and didn't mention that you need to warp out before killing her deserves to get shot in the face

          • Anonymous

            21 Mar 2020 10:46  

            Dont kill her after giving the two brain fluids! Keep reloading the area until her head is HUGE, otherwise she'll still be mortal and die permanently like she did for me

            • Anonymous

              12 Jan 2020 10:51  

              Oh one drops off Adeline and she respawns after thats cool, accept not when you forget to mention thats after giving her the first two and leading people to kill her early wherein she doesn’t respawn. Change the headass retard description.

              • Anonymous

                22 Jan 2017 16:34  

                "The cerebral patients would imbibe water, and listen for the howl of the sea."

                I wonder if this has to do with hyperhydration, or "water intoxication." When a person drinks too much water, their cells often become oversaturated, especially in the brain. This causes severe headaches, as well as delusions.

                It seems also to tie in with the medical condition, hydrocephalus, in which an excess of spinal fluid and/or water in the brain causes a child's head to enlarge. In some cases, the skull becomes incapable of encasing the brain.

                Which begs the question... Is there a possibility that "paleblood" is nothing more than water? Or at least, is paleblood simply the plasma within our blood, devoid of its cellular and genetic content? After all, much of the arcane attacks in the game are represented by either water or ice, and there's the obvious correlation to the "Bulwark Sea..."

                • Anonymous

                  04 Aug 2016 17:22  

                  Hi there, Somehow I forgat to take which fluid guarded by hunter and then I opened living failures boss. Finally simon appeared. Is there any possible way to take it ??

                  • Anonymous

                    05 Jul 2016 08:33  

                    Each Brain Fluid has its unique description. The one listed us the description for the final one (from Adeline).

                    • Anonymous

                      05 Jul 2016 08:33  

                      The badge is in a room to the right where the chandelier falls go right of the staircase and go into a hallway where a brainsucker is and the corpse should be in that hallway

                      • Anonymous

                        05 Jul 2016 08:33  

                        the A.I is still dumb so make the hunter follow you up to the top of the stairs with no handlebars then either make him dash off or push him off with the combat axe

                        • Anonymous

                          05 Jul 2016 08:33  

                          I can't kill one of them. It just keeps on reviving immediately after I kill it and I can't get the fluid

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