Isz Chalice is an Chalice Item in Bloodborne. Combining the Materials listed below in the Chalice will create a Chalice Dungeon. You must be at the Tomb Altar in Hunter's Dream to do this.
| "A chalice that breaks a labyrinth seal.
Great chalice unlock deeper reaches of the labyrinth. The Great Isz Chalice became the cornerstone of the Choir, the elite delegation of the Healing Church.
It was also the first Great Chalice brought back to the surface since the time of Byrgenwerth, and allowed the Choir to have audience with Ebrietas"
- Defeating Ebrietas, Daughter of the Cosmos (Located in Alter of Despair)